Longevity and healing in a pill Dasatinib/Quercetin 50/500 mg pill

The Power of Quercetin

  Quercetin, found in many fruits and vegetables, was one of the first plant-derived flavonoids to be studied as a senolytic.49

Quercetin has numerous benefits, including anti-inflammatory properties that protect cells and tissues from harm.50-54

• Lab studies have shown improved aging markers and longer lifespans (55-60), while human research have shown reduced or prevented age-related illness and dysfunction.61,62

The medical research supporting quercetin's senolytic actions has grown over the years.32,33,35,60,63-65

In a study released in late 2019, quercetin was found to successfully eliminate senescent cells from mice's kidneys. This increased function and reduced the fibrosis (scarring) that causes renal failure.49

Quercetin may be difficult to absorb.66 Scientists solved this problem by mixing it with a sort of fatty molecule known as a phospholipid. The phospholipid acts as a carrier, allowing far more quercetin to enter the bloodstream and spread its effects throughout the body.67

INTERMITTENT VS. CONTINUAL THERAPY: WHICH SENOLYTIC PROGRAM IS MORE EFFECTIVE?

There is a lot of dispute in the longevity field concerning the best treatment strategy for senolytic medications.

For the time being, intermittent therapy appears to be the most effective strategy for lowering senescent cells.32,33,64 Drugs that inhibit the production of pro-inflammatory chemicals released by senescent cells, for example, appear to be more effective when administered intermittently.76

Based on known preclinical data, taking high dosages of quercetin once a week looks to be the best senolytic method.

Enhancing Quercetin's Effects

According to research, quercetin performs much better when used with the chemotherapeutic medication dasatinib.

When this mixture was given to elderly mice, its ability to remove senescent cells resulted in gains in grip strength, coat condition, mobility, and overall health.32

The first human study involving this combination was published in 2019. Patients with idiopathic pulmonary fibrosis (a progressive lung condition) were treated for three weeks with 100 mg/day dasatinib and 1,250 mg/day quercetin.68

This increased numerous physical activity metrics, such as walking distance and speed.

Scientists sought to identify a molecule that would improve quercetin's senolytic actions through the same pathways as dasatinib, but without the adverse effects of a cancer treatment.69-72

Theaflavins, a collection of molecules present in black tea, emerged as the most effective candidate.

  Cell load provides a two-pronged technique for combating the enemy of lifespan.

Quercetin works through different and complementary processes to rid the body of senescent cells.

A multi-targeted method based on highly absorbable quercetin and dasatinib can tackle cellular senescence from various aspects, helping to free the body of the damage it causes.

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